Endocrine Abstracts

Phosphoinositide 3-kinase (PI3K) signalling pathways are now accepted to be widely important in the mechanisms by which a variety of cell surface receptors can regulate critical cellular functions, such as cell growth, survival and movement. Class I PI3Ks generate the messenger lipids PtdIns(3,4,5)P3 and PtdIns(3,4)P2 in the inner leaflet of the plasma membrane. These two lipids then co-ordinate the regulation of multiple protein targets by binding, with ...

Objective: to investigate whether periconceptual undernutrition in sheep alters the timing and activation of the fetal HPA axis and thus pregnancy duration. Preterm birth is a major health problem, but its causes are poorly understood.Methods: Twentyeight nulliparous ewes were randomly assigned to an ad libitum (N, n=8) or restricted diet (maternal body weight reduced by 15-20%; UN, N=10) from 61 d before to 30 d after mating. Therea...